Investigation of Phase I Metabolism for Piperine in Rats
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منابع مشابه
Protective effects of piperine on lead acetate induced-nephrotoxicity in rats
Objective(s): In this study, we investigated the protective effects of piperine on lead acetate-induced renal damage in rat kidney tissue. Materials and Methods: Forty male rats were divided into 5 groups: negative control (rats were given aquadest daily), positive control (rats were given lead acetate 30 mg/kg BW orally once a day for 60 days), and the treatment group (rats were given piperine...
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Introduction: Paraquat triggers oxidative stress and apoptosis. This study aimed to explore the effects of 7-week aerobic training and piperine supplementation on oxidative stress markers of brain tissue in male Wistar rats exposed to paraquat. Materials and Methods: Forty-eight adult rats were divided into 6 groups: 1) sham, 2) paraquat (negative control), 3) paraquat+training, 4) paraquat+tra...
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Abstract Introduction: There is limited knowledge available on the metabolism of glucose in the brain, an insulin insensitive organ. Insulin receptors hybridize with insulin like growth factor receptor (IGF-I) to transduce the signals in different areas of the brain. In this article we aimed at investigating whether the expression of IGF-I receptor and IGF-I binding proteins (IGFBP1) is change...
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Although linarin possesses diverse pharmacological activities, its poor oral bioavailability has been a concern for further development. The present study aimed to demonstrate the feasibility of improving the oral absorption of linarin in rats with a bioenhancer‒piperine. First, the intestinal permeability of linarin in the presence and absence of verapamil or piperine was investigated using an...
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